Senior Scientist

Company: F. Hoffmann-La Roche Gruppe
Location: Seattle
Posted on: May 31, 2025

Job Description:

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.The PositionWe advance science so that we all have more time with the people we love.Roche Diagnostics acquired Stratos Genomics in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by Expansion (SBX). You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes. We are looking for people who are excited about the significance of our technology and want to make SBX successful.The Opportunity:

• Research, design and execute innovative and well-controlled experiments, with high attention to detail.
• Lead, mentor and drive cross functional teams
• Identify and troubleshoot problems in creative ways.
• Contribute to the definition and timely achievement of project goals.
• Develop SOPs to aid in the production of reagents and starting materials
• Participate in the production of reagents and starting materials.
• Perform data analysis and protocol development.
• Maintain accurate, detailed and reliable laboratory records.
• Present findings at group or departmental meetings.
• Maintain the lab's cleanliness and organization.
• Develop and propose improved processes to fulfill the above functions.Who You Are:
  • You have 6 years of laboratory experience in advanced nucleotide/heterocyclic chemistry, phosphorus chemistry and/or complex/multi-step organic synthesis.
  • You have a Bachelor's degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 8 years of experience or you have a Master's degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 7 years of experienceor you have a PhD Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 4 years of experience
    • Ideally, you will have:
      • Demonstrated ability to understand and develop chemistry for:
        • Nucleotides
        • Phosphoramidites
        • Heterocycles
        • Amino Acids
        • Bio-conjugations
        • Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage.
        • Technical background in next-generation DNA sequencing
        • Experience with HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting.Your application must include a cover letter addressing the following:
          • Clearly state your motivation for wanting to work with us.
          • Describe your specific technical interest in SBX technology and how you envision contributing.
          • Outline potential interesting challenges related to the molecular engineering of SBX technology and propose your solutions.Submitting a comprehensive cover letter that addresses these points is necessary.
            Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of Seattle, WA is $94200-175,000 Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.This position also qualifies for the benefits detailed here:Relocation benefits are available for this posting.Who we areA healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
            Let's build a healthier future, together.Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form .
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Keywords: F. Hoffmann-La Roche Gruppe, Tacoma , Senior Scientist, Other , Seattle, Washington